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Although HCV-1b has been encountered more often in patients who acquired HCV through blood transfusion[16] (the prevalence of HCV-1b has decreased concurrently with the implementation of screening of blood and blood products for HCV), HCV-3a has been associated with intravenous drug use (IVDU),[17] tattooing and piercing.[18] A unique worldwide epidemic among drug abuser communities has been proposed because nonstructural protein (NS) 5B of HCV-3a showed similar sequences in intravenous drug users across different countries,[19] suggesting a common origin (apparently emerged and diversified in Asia)[20] of the outbreak

The CD36 and SCARB1 genes encode closely related multi-ligand receptors that are most recognized for their roles in lipid and lipoprotein metabolism