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The value of IV B12 lies in its efficiency
Indirect evidence of the efficacy of exposure to thiol-binding metals at environmental and occupational levels to induce oxidative stress and to decrease the glutathione pool emerges also from the study of biomarkers such as antioxidant enzymes and soluble oxidized metabolites [28,29,30,31]

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Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: From cofactors to antioxidants to redox signaling
