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A balanced -6/-3 ratio is indeed important to support the anti-inflammatory profile of -3 PUFA, and a varied diet should include balanced amounts of each PUFA class with a predominance of -3

Moreover, animal models (131) and tissue specimens obtained from patients with sarcoidosis (132) showed that hyperproduction of Th2 cytokines is accompanied by tissue macrophage activation and differentiation toward the M2 phenotype, which contributes to the development and maintenance of tissue foci of chronic inflammation, the formation of granulomas, and foci of fibrosis

doi: 10.1093/hmg/ddn184 [DOI] [PMC free article] [PubMed] [Google Scholar] 494

The study must be approved by an independent ethics committee, and every participant must give informed consent meaning they've received clear, honest information about what the study involves, what the risks are, and that they're free to withdraw at any time