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Since BDR-4 is an established driver of angiogenesis and microvascular repair, viral exploitation of this protein likely alters the biological barriers, enabling microbial translocation and the ME/CFS pathogenesis (Maes and Leunis, 2008
Among the roles of the NADPH-dependent disulfide reductase systems, the most universal is that they provide the reducing power for the production of DNA precursors by ribonucleotide reductase (RNR)
The formal reclassification is still pending
