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Readers exploring how the same fragment has been proposed to act in entirely different tissues the brain, for instance can see a parallel example of preclinical-mechanism reasoning in the discussion of the molecular mechanisms proposed for AOD-9604 in obese phenotypes, where the same caution about extrapolating from limited data applies

Conflict of Interest The authors have declared that no conflict of interest exists

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide