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In some cases, startups not primarily located in the US can fulfill these criteria if they make significant contributions to the US economy through paying taxes or using American products, materials or labor
Retinoid discontinuation creates the benchmark comparison since topical vitamin A derivatives (tretinoin, adapalene, retinol) represent gold-standard anti-aging treatment with decades of research and user experience documenting post-treatment outcomes
References: AGS (2023): American Geriatrics Society 2023 updated AGS Beers Criteria for potentially inappropriate medication use in older adults
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