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Importantly, under oxidative stress conditions, BH 4 is rapidly oxidized to BH 2 by superoxide anion or, especially strongly, by peroxynitrite derived from NO scavenging by O 2 [76]
Methods Enzymol
[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Schmidt S, Jrgensen M, Chen Y, Nielsen R, Sandelin A, Mandrup S

However, genetic predispositions alone do not indicate whether glutathione co-therapy is necessary
