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In summary, protein acylation of metabolic enzymes or nutrient transporters always modulate the progression of different diseases by regulating glucose, fatty acid and amino acid metabolic reprogramming

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ZDHHC20 palmitoylates EGFR on the C-terminal domain (C1025) to promote its ubiquitination-mediated lysosomal degradation, thus upregulating p85 binding and phosphatidylinositol 3-kinase (PI3K) signaling and inhibiting Grb2 binding and MAPK signaling