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Bioenergetic role of mitochondrial fusion and fission

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We confirmed, circulating TMAO significantly increased with cardiometabolic disease severity, in line with previous reports 7,22 (Supplementary Fig

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Accordingly, TMAO is one of the bystanders rather than the single and direct causative agent of vascular complications of CKD

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There are three main hepatic isoforms of the FOXO transcription factors (FOXO1, FOXO3, FOXO4), and all three are implicated in regulating cell growth and insulin-stimulated glucose and lipid metabolism (118, 132)

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