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Activated pancreatic stellate cell (PSC), the main stromal cell of PDAC, accounts for 50% of the stroma and is comprehensively implicated in PDAC metabolic imbalances, including reprogramming of stroma and energy metabolism 9
These patients often undergo repeat and unnecessary investigations and procedures
(2013) characterized the role of NNMT in cancer cell metabolism, demonstrating that NNMT activity creates a metabolic sink for SAM
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