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This may directly affect gene transcription or recruit transcription factors to specific promoter regions

Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley GP Jr (2012) Association of biochemical B12 deficiency with metformin therapy and vitamin B12 supplements: the National Health and Nutrition Examination Survey, 19992006

10:e00926

Disruption of intestinal barrier function may trigger development of local and even systemic inflammation
