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Data availability Structural data for the SARS-CoV-2 3CL protease in complex with DEL2, DEL7, 1 , 2 , 14 , 15 , 16 , 17 , 25 , 27 , 28 , 29 , 30 , 31 , 32 , and 46 were deposited in the Protein Data Bank (PDB), with accession codes PDB IDs: 8UDJ, 8UDF, 8UDQ, 8UDW, 8UDP, 8UDO, 8UDM, 8UDX, 8UDY, 8UEG, 8UEI, 8UEA, 8UEB, 8UEH, 8UEF, and 8UE0

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