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Regarding publication bias, we did not perform a de novo funnel plot or Eggers test on the set of included systematic reviews, given the aggregated nature of the data
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Similarly, in a model of PD caused by MPTP, ALGERNON2 reduced the release of proinflammatory cytokines and stabilized the cyclin D1/p21 complex by inhibiting Dyrk1A activity, leading to Nrf2-dependent antioxidant and anti-inflammatory responses [121]
