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Findings from animal models further support these observations, demonstrating that serum lactate levels are consistently elevated in monocrotaline-induced PH [57]
Meanwhile, clozapine can disrupt lipid metabolism in the liver by affecting L-Car reabsorption, and concurrent L-Car supplementation is an effective strategy to mitigate these metabolic disturbances (Bruno et al., 2016
Autophagy also plays a role in eliminating damaged proteins and subcellular organelles to sustain cell viability, while unrecoverable damage can trigger cell death (106)
doi: 10.30773/pi.2016.12.31
