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Glossary Biomarker typically a metabolite or protein that is released from tissues in association with exposure to a chemical agent and subsequent effects on target organs Physiologically based pharmacokinetic (PBPK) model a mathematical model of how a chemical enters the body, translocates between tissues, is metabolized, and is excreted Cytochrome P450 (CYP) family of heme-containing enzymes that catalyzes a diverse array of reactions, including oxidation of TCE Glutathione S -transferase (GST) family of enzymes found in most tissues but especially the liver that catalyze the conjugation of electrophilic substrates with glutathione Target organ toxicity specific adverse effects from a chemical exposure on specific organs or organ systems Mercapturate an N -acetyl-l-cysteine conjugate that is the terminal metabolite derived from glutathione conjugation and is often recovered in urine S -(1,2-dichlorovinyl)-l-cysteine (DCVC) cysteine conjugate derived from conjugation of TCE with glutathione

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Binding mode analysis of zerumbone to key signal proteins in the tumor necrosis factor pathway