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Description
So, the resistance of GSH-EPT conjugates to P-glycoprotein efflux pump has been considered as a breakthrough on development of the epothilone derivative as cancer chemotherapeutic drug

Here, we reveal that the aldehyde derivative of UNC10088 promotes cooperative binding of FBXO22 to NSD2, a histone methyltransferase and oncogenic protein, leading to a cryo-EM structure of the SKP1-CUL1-F-box (SCF)-FBXO22 complex with NSD2

G.SerranoG
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