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doi: 10.1172/JCI200422087

Clinical symptoms result from binding of IgM to red cells in vascular beds where the temperature may fall below 30C, such as in exposed fingers, toes, and ears

Furthermore, in models of Alzheimers disease (AD) and tauopathy, this intervention eliminates amyloid- and pathological tau, leading to improved memory performance

[Google Scholar] 12.Branco-Ferreira M., Clode M.H., Pereira-Barbosa M.A., Palma-Carlos A.G