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TB-500 is a synthetic active fragment of thymosin beta-4, a naturally occurring intracellular protein

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However, based on related compounds and user reports, potential side effects may include: Injection site irritation (redness, itching, or tenderness) Fatigue or drowsiness Possible disruption of glucose metabolism Increased hunger or short-term blood sugar fluctuations Older research from 1978 found that similar C-terminal HGH fragments caused temporary rises in blood glucose and insulin levels in animals, indicating possible insulin sensitivity issues

In mesenchymal cancer stem cells, NNMT overexpression depleted intracellular NAM and therefore enhanced the activity of PARP1, increasing the chemoradiotherapy resistance of cancer cells [48]