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However, overactivation or a failure to resolve their activation status (chronic activation from continued exposure to pro-inflammatory stimuli) can lead to the increased ECM deposition in the space of Disse that has a negative consequence for hepatocyte function and normal liver architecture, such as loss of microvilli [80,82]
X-GEN Pharmaceuticals, Inc
Hoffstrom, B
However, the use of oncogenes or retrovirus in the current iPS cell establishment protocol raises considerable safety concerns (Pasi et al., 2011)
