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Genomic and meta-genomic data have revealed that co-evolution between viral and cellular genomes involves frequent horizontal gene transfer and the occasional co-option of novel functions over evolutionary time 784 , the virus-induced HMRD with PASC, is one such prime example
This results in small, discoloured patches that can appear lighter or darker than the surrounding skin
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These observations indicate that immune activation is an additional mechanism that can contribute to response to anti-angiogenic therapy
