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Experimental evidence using a high-iron diet demonstrated that increased iron levels favored Tfh and GCB cell expansion, enhanced secretion of inflammatory cytokines IFN- and IL-17A by CD4 + T cells, promoted autoantibody production in MRL/lpr lupus mice, and worsened their disease phenotype

[DOI] [PubMed] [Google Scholar] 8.Guan X

[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Powell E.E., Wong V.W., Rinella M

These effects were mediated by the upregulation of myelin basic protein (MBP) in C57BL/6 mice treated with 3.02 g/kg of the capsule for 40 days, underscoring its neuroprotective potential (Zhao et al., 2020)