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Biological Chemistry Hoppe-Seyler
The protective effects of SFN against oxidative damage have been studied in various in vitro [27] and in vivo [28] models and recently, the role of Nrf2 activity in modulating innate immune responses has been investigated in sepsis [29]
The key molecular pathway identified involves the activation of the general control nonderepressible 2 (GCN2) kinase, leading to the phosphorylation of eukaryotic initiation factor 2 alpha (eIF2) and the upregulation of ATF4
