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In such an environment, a certain release of Al species from the clinoptilolite surface may well be hypothesized even though aluminum from the clinoptilolite materials does not enter the blood or accumulate in the body as shown in athletes supplemented with zeolite-clinoptilolite supplement (Lamprecht et al., 2015) or healthy rats supplemented with different clinoptilolite materials (Kraljevi Paveli et al., 2017) where aluminum released into systemic circulation was observed only in rats supplemented with synthetic zeolite A

In both in-vitro and in-vivo, it has been shown that introducing miR-34 through AdCN205-miR-34a infection leads to a decrease in the levels of SIRT1 and Bcl-2 proteins

doi: 10.3390/ijms23031224

officinalis extract, respectively