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Figure 1 1.3 Bile acid receptors, rationale, and scope of this review The immunomodulatory effects of BAs are primarily transduced through a repertoire of host receptors, including nuclear receptors like the Farnesoid X receptor (FXR) and Vitamin D receptor (VDR), and G protein-coupled receptors such as Takeda G protein-coupled receptor 5 (TGR5) and Sphingosine-1-Phosphate Receptor 2 (S1PR2) ( 2 Bile acid-mediated regulation of immune cell populations and functions within the TIME Bile acids (BAs) regulate the TIME through a spectrum of diverse mechanisms

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p-tau, phosphorylated tau