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Humans also express a mitochondrial version of 10-FTHFDH which is encoded by the ALDH1L2 gene
The reason why the natural ligand of mGluR1 (glutamate) but not the synthetics agonist (quisqualate and DHPG) increased in cell viability is not well known, but the internalization of glutamate could be necessary for mGluR1 to induce effects on melanoma cells
Milk Thistle

Berendsen, S
