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It has been demonstrated that a decrease in GS deficiency results in the inhibition of various signaling cascades associated with glutamine metabolism

Digoxin is very tightly bound by the tissues and not held in the plasma: the drug appears to be dissolved in a large volume and thus the V d is large (6L/kg)

Deli, Bosnyak, Pusch, Komoly, & Feher, 2013)

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