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A trace of DMSO: a small percentage can help genuinely stubborn hydrophobic peptides dissolve, but use the minimum that works, since DMSO can interfere with some downstream assays

In other words, the policy direction is clear, but the regulatory mechanics are still working their way through the system

Off-label products are not endorsed by the FDA

Future studies should focus on leveraging single-cell multi-omics technologies to comprehensively characterize the dynamic changes of macrophages within the pulmonary vascular microenvironment, developing cell-specific delivery platforms for precise intervention, and exploring individualized therapeutic strategies based on macrophage phenotyping