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NICE-approved weight management interventions include: Dietary and lifestyle modification first-line approach for all patients Orlistat licensed medication for obesity (BMI 30 or 28 with comorbidities) GLP-1 receptor agonists including semaglutide (Wegovy) per NICE TA875 and liraglutide (Saxenda) with restrictions per NICE TA664, for specific patient groups Bariatric surgery for severe obesity meeting strict criteria The NHS emphasises that sustainable weight loss requires behavioural change, nutritional education, and increased physical activity

Proc Natl Acad Sci 106(29):1182511826 La Morgia C, Maresca A, Amore G, Gramegna LL, Carbonelli M, Scimonelli E, Carelli V (2020) Author Correction: Calcium mishandling in absence of primary mitochondrial dysfunction drives cellular pathology in Wolfram syndrome

Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance