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MTHFR Gene Polymorphisms and Susceptibility to Rheumatoid Arthritis: A Meta-Analysis Based on 16 Studies
Gan Y, Zhou X, Niu X, et al
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Many proteins are susceptible to aggregation, degradation (e.g., via deamidation/oxidation in vitro, through proteases in vivo, etc.), and denaturation which can significantly reduce efficacy 16,17
