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Their polycationic nature binds transition metals such as Fe 2+ and Cu 2+ , preventing hydroxyl radical generation and limiting propagation of lipid peroxidation [221,222]

It has been shown that exogenously administered vitamin E down-regulates the expression of cell adhesion molecules in both untransformed primary cells and the A549 and BEAS-2B cell lines and suppresses the synthesis of the neutrophil chemoattractant IL-8 [41]

In published reviews of cell biology, glutathione is described as a central redox factor and enzymatic cofactor that functions across a wide range of cellular processes (Covarrubias et al., 2021)

As a transcription factor, it governs glucose and lipid metabolism, inflammation, and cell proliferation