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The FDA recommends using a non-oral contraceptive method or adding a barrier method for 4 weeks after starting treatment and for 4 weeks after each dose increase

The effective size is such that approximately 10% of the total grains by weight are smaller and 90% are larger

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The STEP 5 trial demonstrated that continued treatment for 104 weeks maintained weight loss, while the STEP 1 extension study showed that discontinuing semaglutide at 68 weeks led to two-thirds of the weight lost being regained within a year