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GH plays a role in dermal thickness and collagen biosynthesis, reversing age-related skin changes (Laron, Pediatric Endocrinology Reviews )
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10.1016/j.bpj.2009.03.053
in Cell Metabolism , increased NAD availability stimulates PGC-1 through SIRT1 activation, leading to enhanced mitochondrial function and improved metabolic flexibility (Cant et al., Cell Metabolism )
