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Another mitochondrial autophagy regulator, nuclear factor erythroid 2-related factor 2 (NRF2), is a key regulator of cellular redox homeostasis and also impacts mitochondrial function

Nishimura and colleagues showed that loss of ATM in melanoblast stem cells within the hair follicle bulge region in mice could sensitize the stem cells to genotoxic stress, leading to early differentiation, depletion from the niche and progressive hair greying over subsequent cell cycles due to eventual depletion of mature melanocytes from the hair bulb 3,10

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indicates downregulation (decrease)