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In this context, for instance, the pharmacokinetic profile needs to be defined in detail, including the type of metabolic enzymes involved in its degradation, interactions resulting from the binding of the drug to plasma proteins, etc
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Common causes in the UK include pernicious anaemia (an autoimmune condition where the stomach fails to produce intrinsic factor, a protein essential for B12 absorption) and dietary deficiency, particularly in those following strict vegan diets (as B12 is found primarily in animal products)
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