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In Phase 3 TRIUMPH-4 (Eli Lilly, December 11, 2025), the 12 mg arm averaged 28.7% body weight loss at 68 weeks

Animal studies suggest it can restore esophageal sphincter tone and reduce inflammation, which may benefit chronic reflux sufferers
A high-protein diet including legumes and fish seems to be best for increasing testosterone (12)

Retatrutide, a triple-receptor agonist still in Phase 3 clinical trials, has posted some of the most impressive weight loss numbers ever recorded in obesity research, hitting 24.2% body weight reduction in 48 weeks
