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Experimental studies report activation of signaling mechanisms related to vascular remodeling, including Notch-associated pathways and endothelial cell activation in angiogenesis models [8]

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This system includes enzymes like superoxide dismutase (SOD), catalase (CAT), heme oxygenase (HO) and glutathione peroxidase (GPX), as well as non-enzymatic antioxidants like vitamin E, vitamin C, and glutathione (GSH), which act as antioxidant scavengers [6]

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Meibomian glands, which are holocrine glands located at the lid margin of the conjunctiva, produce the lipid portion of the tear film

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