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Alternatively, endocytosis and/or transcytosis of GSH transporter-targeted ligands may be assayed by in vivo bioimaging techniques using for instance near-infrared dyes or radioactive labels conjugated thereto, resulting in at least 10, 20, or 50% enhanced retention in CNS area of the ligand at given time-points (based on region of interest (ROI) pixel quantification), as compared to appropriate control conditions (e.g., comparison to reference compounds lacking GSH moieties)

[258] found higher levels of nicotinamide (vitamin B3) in the plasma of asthmatics, probably due to an increased consumption of NAD+ in the course of immunologic activation in asthma

GSH reaches millimolar levels (110 mM) within cells, micromolar levels (1030 M) in plasma, and its low redox potential (E 0 = 240 mV) makes GSH an ideal cellular redox buffer 581,582

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