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The metabolism and elimination of NAD+ (and its by-products) could be altered in advanced hepatic or renal dysfunction, and high-dose NAD+ might theoretically affect cardiovascular dynamics, so practitioners generally avoid or closely supervise NAD+ use in such settings
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doi.org/10.1038/nature05383 Chang, C
They were randomly assigned in the ratio of 1:1:1 to once-weekly subcutaneous CagriSema (n=31), semaglutide (n=31), or cagrilintide (n=30) (all escalated to 24 mg)
