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In 2015, Lantos and colleagues reviewed the geographic expansion of Lyme disease in the Southeast and found a marked increase in Lyme disease cases in Virginia, particularly from 2007 onwards with development of a new disease cluster in the southern Virginia mountain region. Since 2009, five counties in North Carolina have been considered endemic for Lyme disease

Neutrophils produce a mixture of proteins from primary granules (azurophilic), secondary granules (specific) and tertiary granules, content of these granules has an antimicrobial function and help in eliminating infections