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Results FXN expression is decreased in FA iBMVEC iPSCs derived from a 49-year-old apparently healthy male and a 34-year-old male with FA have differentiated into brain microvascular endothelial cell-like cells (iBMVEC), as previously described (Foreman et al., 2023)

Overexpression of PDI counteracts NMDAR-induced ER stress, and this protective effect depends on the cysteine residues at its active site (Uehara et al

Most recently we have been successful in creating a tripeptide analog (eg

sobolifera (Hill ex Watson)) transmit TLR4 signaling to MAPK pathway and extracellular signal-related kinase one and 2 (ERK1/2) activation backing Treg/Th2 induction