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Description
Molecules 16:99129924
In cancer, inducers of ferroptosis, such as erastin and RSL3, take advantage of the high levels of iron and PUFAs in tumor cells [94, 95], while inhibitors like fer-1 and liproxstatin-1 show potential in treating neurodegenerative diseases, including Alzheimers, where lipid peroxidation contributes to neuronal damage [96]
Thus, it is thought that ERdj5 recognizes misfolded substrates by virtue of their association with EDEM, reduces them, and then transfers them to the ERAD machinery
Abstract The future GCC-connected environmental risk factors expedited the progression of nCDs
