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CCK-8 assays identified time-dependent cytotoxicity of CM#2 on chondrocytes, reducing viability to 65.2% (24 h) and 49.3% (48 h)

The NLCs were then formulated into gel for in-vivo animal studies where they showcased minimal hyperkeratosis and gave results near to standard treatment protocol

Other peptides, particularly epitalon for telomere biology, GHK-Cu for dermal aging, and Semax for cognitive aging, show promise but require systematic clinical validation

doi: 10.1186/s12906-018-2194-9