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Pelacarsen, a second-generation antisense oligonucleotide, is covalently bound to N-acetylgalactosamine (GalNAc), which provides uptake via asialoglycoprotein receptors located on hepatocytes, thus improving the potency and safety of the medicine
doi: 10.1016/j.amjcard.2009.07.063
Digestive issues: Creatine has been reported to cause some mild digestive issues, such as diarrhoea or stomach pain, particularly when taken in high amounts, but may cause complications if left unattended
