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Description
In pregnant rabbits given once weekly subcutaneous doses of 0.01, 0.03, or 0.1 mg/kg tirzepatide (0.01-, 0.06-, and 0.2-fold the MRHD) during organogenesis, pharmacologically-mediated effects on the gastrointestinal system resulting in maternal mortality or abortion in a few rabbits occurred at all dose levels
It binds with very high affinity to angiotensin 1 receptor and displaces angiotensin II from the receptor
10.1038/ncb1857 35 PariharN.BhattL
Additionally, its counteracting effect occurred even with pre-existing adhesions (Berkopic Cesar et al., 2020)
