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Down's syndrome, longevity and Alzheimer's disease
doi: 10.1021/acs.accounts.9b00562 [DOI] [PMC free article] [PubMed] [Google Scholar] Shin Y, Brangwynne CP
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DADS inhibited cell proliferation by increasing tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP2 mRNA levels and proteins while decreasing claudin proteins (claudin-3, claudin-4, and claudin-2), which are important components of tight junctions (TJs) (Park et al., 2011)
