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P-glycoprotein is expressed in epithelial cells related to the drugs absorption and distribution, e.g., in the tubular membrane of hepatocytes, proximal renal tubules, intestinal mucosa, and brain capillaries [80]
Cognitive and Neuroprotective Benefits of BDNF-Boosting Diets Diets that up-regulate BDNF are co-related with improved cognitive performance in at risk populations such as senescence and in neurodegenerative diseases
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This alteration can lead to excessive ROS production, damaging VECs and causing mitochondrial dysfunction
