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Meanwhile, ROCK can enhance the transduction of transforming growth factor-1/suppressor of mothers against decapentaplegic homolog signaling [40], thereby inducing endothelial-to-mesenchymal transition, increasing fibrosis markers, and structural remodeling of the microvasculature in the CC [41]

doi: 10.1176/appi.ajp.2020.20091382 [DOI] [PubMed] [Google Scholar] 14.Veech RL

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The method of claim 1, wherein the composition is applied to spider vessels of peri-menopausal, menopausal, or post-menopausal skin