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Some community members are running this sequence deliberately: start with NAD+ precursors (NMN/NR) to raise the baseline pool, then add MOTS-C to put that pool to work, then layer in 5-Amino-1MQ to block the pathway that drains it
NAD+ raised higher NAD+ feeds mitochondrial energy production and switches on sirtuin enzymes
The what happens when you stop GHK-Cu article discusses how results change with discontinuation and can inform decisions about ongoing use versus cycling
