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One reason could be that in vivo-studies are much more expensive and sophisticated

Vitamins C and E: Enhances their lifespan and effectiveness

Other than designing peptides that competitively bind to the CatB/L protease, peptides that inhibit endosomal acidification can also be used to inhibit the activity of CatB/L and other host cell proteases that is pH-dependent [93, 94]

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