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The value of long-term albumin administration was investigated in the ANSWER study, a multicenter, randomized, open-label trial that assigned 440 patients with cirrhosis and uncomplicated ascites resistant to diuretic therapy to receive either standard medical therapy or standard medical therapy plus albumin (40 g twice weekly for 2 weeks, and then 40 g weekly) for up to 18 months

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Additionally, genetic studies have uncovered a fascinating link: a naturally occurring variant of the MOTS-c peptide (in which a single amino acid, glutamate, is replaced by lysine at a certain position) has been associated with exceptional longevity in some populations